Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (35): 6555-6558.doi: 10.3969/j.issn.1673-8225.2010.35.024

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MRI imaging of the ischemic penumbra in rat models of acute cerebral ischemia/reperfusion: An analysis based on mathematical model

Gao Wei1, Yang Kun2, Ling Xiao-zheng1, Yang Jing1, Zhang Xue-jun3, Hao Rui-sheng4   

  1. 1 Department of Mathematics, Basic Medical College of Tianjin Medical University, Tianjin  300070, China; 2 Tianjin Anding Hospital, Tianjin  300200, China; 3 Imaging College of Tianjin Medical University, Tianjin  300203, China; 4 Tumor Hospital of Tianjin Medical University, Tianjin  300060, China
  • Online:2010-08-27 Published:2010-08-27
  • Contact: Hao Rui-sheng, Attending physician, Tumor Hospital of Tianjin Medical University, Tianjin 300060, China
  • About author:Gao Wei★, Master, Lecturer, Department of Mathematics, Basic Medical College of Tianjin Medical University, Tianjin 300070, China gaowh_3@126.com
  • Supported by:

    a Grant from Tianjin Medical University, No. 2008ky01*

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Abstract:

BACKGROUND: Most scholars believe that generalized ischemic penumbra (IP) was located in the hypoperfusion area next to severe ischemic region, and is a dynamic state. It is a key point for therapy to successfully remedy IP. MRI can observe area of brain ischemia, but the data cannot directly reflect changing rules between ischemia duration and infarct area. 
OBJECTIVE: To observe the effect of mathematical model in MRI imaging of rat models with acute cerebral ischemia/reperfusion.
METHODS: The model of ischemia was established by obstructing middle cerebral artery occlusion. The model rats were divided into ischemia and neuroprotective agent groups (breviscapine injection following ischemia). DWI was performed in 0.5-48 hours. Apparent diffusion coefficient (ADC) in different areas of ischemic focus was measured and relative magnitude of ischemic areas and opposite side areas were calculated. Data processing was performed by using least square method, and the results of functional relation formula between ischemic time and infarct size was concluded, followed by linear analysis.
RESULTS AND CONCLUSION: Ischemic time (X) was negatively correlated with relative ADC (Y) during 9-21 hours in points 3 and 4 in rat models of acute cerebral ischemia/reperfusion, and there was significant linear correlation. Those regression equations were following as: y=1.458 153-0.042 770 333x, y=1.510 346-0.037 141 333x. There was significant linear correlation during 1-6 hours in all points of neuroprotective agent group (r > 0, P < 0.05). From 24 to 48 hours, the rADC of all points was increased with time. Results showed that 1-6 hours is an important period for neuroprotection in rat models of acute cerebral ischemia/reperfusion.

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