Abstract:

OBJECTIVE: To comprehensively evaluate the application of polysulfone membrane, hemophan membrane and cellulose acetate membrane in the process of maintenance hemodialysis, to select appropriate membranes for hemodialysis.
METHODS: Chinese Academic Journal Full-text Database (CNKI: 1990/2008) was retrieved for articles related to the clinical application of different dialysis membranes using “dialysis membrane, compatibility, complications” in Chinese as the key words, totally 50 articles were screened out. Reviews, experimental studies and articles on dialysis membrane cleaning were excluded, 22 articles related to solute clearance rate and biocompatibility of different dialysis membranes were included, the clinical application of blood dialysis membranes of different materials was comprehensively summarized.
RESULTS: Based on the analysis of solute clearance of polysulfone membrane, hemophan membrane and cellulose acetate membrane in maintenance hemodialysis, the effect of polysulfone membrane and hemophan membrane on clearing intact parathyroid hormone, phosphorus, calcium was better than that of cellulose acetate membrane, the clearance of B cell activated serum CD23 was better than cellulose acetate membrane. As for the platelet activation, the two were weaker than cellulose acetate membrane. Polysulfone membrane with high permeability does not increase inflammation, P-selectin levels dialysis by cellulose acetate membrane were higher than polysulfone membrane and hemophan membrane, three kinds of dialysis membranes had no significant difference on serum cystatin C clearance rate.
CONCLUSION: The effects of polysulfone membrane, hemophan membrane and cellulose acetate membrane on serum CD23 concentration, platelet activation, inflammatory response, clotting complications, P-selectin serum levels were related to the biocompatibility: better biocompatibility indicated few effects, otherwise indicated greater effects. The biocompatibility of polysulfone membrane and hemophan membrane is better than cellulose acetate membrane, of complications of hemodialysis membrane are at least in hemophan membrane.