Abstract:

OBJECTIVE: To summarize the type, biological characteristics and applications of anti-glioma controlled-release drug delivery system vector materials.
METHODS: A computer search was performed in PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI Database (www.cnki.net/index.htm) by screening “lactic acid, vector, interstitial chemotherapy” in Chinese and “Polylactic acid, vector, interstitial chemotherapy” in English as key words in the titles and abstracts. Articles related to controlled-release drug delivery system, polylactic acid, vector and its application effect were included, those in the same field preferred to the recently published literature or published in the authority journals. Thirteen articles were included.
RESULTS: The ideal vector of the delivery system should have good biocompatibility, nontoxic polymers and degradation products, suitable physico-mechanical properties and formability, controlled degradation rate. Currently interstitial chemotherapy of glioma recurrence, that is controlled-release drug delivery system, do not require frequent administration, it can maintain effective drug concentrations in vivo for a long period, thus significantly improving the drug efficacy and reducing toxicity. Compared with intravenous chemotherapy treatment, it has fewer side effects and better efficacy.
CONCLUSION: The biodegradable polymer with good biological characteristics serving as the vector of the controlled-release drug delivery system for interstitial chemotherapy has significant advantages and great development potential.