Abstract:

OBJECTIVE: To summarize the biomechanics and biocompatibility of cardiovascular scaffold materials, as well as vascular restenosis after implantation.
METHODS: The first author conducted a computer search of PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and CNKI database (www.cnki.net/index.htm), with key words of “biological mechanical, biocompatibility, in-stent restenosis” in English and Chinese in title and abstracts. Articles related to material science, biocompatibility and application were selected, those recently published or published in the authority journal were preferred in the same field. Totally 24 literatures were included.
RESULTS: An ideal cardiovascular stent should have good biocompatibility, appropriate expansion ratio, sufficient flexibility and compliance, be easy to disinfect, easily controlled micro-environment. Cells must be ensured to adhere and grow after implantation, with good affinity. Currently, the mechanism underlying restenosis after stenting remains unclear, it becomes increasingly urgent to reduce the incidence of restenosis after implantation. In addition to corrosion resistance, Young’s modulus, yield strength and material compliance, the restenosis after implantation is also related to the inflammatory response after implantation, endothelial cell proliferation, cell hyperplasia of fibrous tissue and other biocompatibilities.
CONCLUSION: The excellent scaffold should have not only reliable and suitable expanding features, excellent visibility and effective controlled micro-environment, but also good biomechanical properties and biocompatibility. At present, biological biodegradable stent has a very good development potential.