Abstract:

BACKGROUND: Current blood/plasma perfusion adsorbents applied in clinics are mainly activated carbon and chemically synthetized macroporous polymer. Carbon window dressing will cause embolism, and resin porogen, most of which is solvent toluene, may be difficult to clean and induce adverse reactions. Natural polymer with amine modified by cross-linking plays a pivotal role in preparation of the adsorbent.
OBJECTIVE: To prepare functional group crosslinked chitosan adsorbent with natural biological polysaccharide-chitosan as a skeletal matrix of bilirubin adsorbent, modified by amination crosslinking, and with sucrose as porogen, to compare with the commercially available BL-300 plasma perfusion adsorbents on the plasma bilirubin adsorption.
METHODS: Functional group crosslinked chitosan adsorbents and commercial BL-300 type plasma perfusion adsorbent were utilized, hyperbilirubinemia plasma was carried out on plasma perfusion tests, plasma bilirubin adsorption rate of different adsorbents was determined using automatic biochemical analyzer.
RESULTS AND CONCLUSION: The functional group crosslinked chitosan adsorbent and commercial BL-300 adsorbent showed good adsorption on plasma bilirubin at various concentrations, the adsorption rate was 50.2% in functional group crosslinked chitosan adsorbent, and 56.8% in BL-300 adsorbent, which was consistent with previous reports. Results showed that the functional group crosslinked chitosan adsorbent is effective, safe and reliable to scavenge bilirubin.