Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (34): 6351-6354.doi: 10.3969/j.issn.1673-8225.2010.34.019

Previous Articles     Next Articles

Effects of an absorbable polysaccharide hemostat PerClot® on fracture healing of the cranial bone

Niu Wen, Liu Yi, Zhang Bo, Luo Ying, Liu Man-ling, Li Zhi-chao   

  1. Department of Pathology and Pathophysiology, Basic Section, Fourth Military Medical University of Chinese PLA, Xi’an  710032, Shannxi Province, China
  • Online:2010-08-20 Published:2010-08-20
  • Contact: Li Zhi-chao, Professor, Doctoral supervisor, Department of Pathology and Pathophysiology, Basic Section, Fourth Military Medical University of Chinese PLA, Xi’an 710032, Shannxi Province, China
  • About author:Niu Wen★, Master, Assistant experimentalist, Department of Pathology and Pathophysiology, Basic Section, Fourth Military Medical University of Chinese PLA, Xi’an 710032, Shannxi Province, China pathophy@fmmu.edu.cn

PDF

923

Abstract:

BACKGROUND: PerClot® is an absorbable polysaccharide hemostat which is made from plant starch. It enables blood components such as fibrin and platelet to congregate, and then it benefits the formation of primary callus.
OBJECTIVE: To observe the effects of PerClot®, an absorbable polysaccharide hemostats, on fracture healing of the cranial bone.
METHODS: Twelve healthy adult New Zealand rabbits were used. Each of them was drilled into two circle cavities in its parietal bone, totaling 24. According to various stuff materials, twelve cavities were equally and randomly divided into three groups: control group, PerClot® group and bone wax group. The defect sites in the PerClot® group and bone wax group were covered with absorbable polysaccharide hemostats and bone wax, respectively. Control group was left intact. After six weeks of treatments, animals were killed. Tissue materials were drawn from the former defective spaces including at least 1.5 cm extention of the cranial bone. Bone healing was generally observed and graded. Bone trabecula and congenital absence areas were measured using the imaging analysis software.
RESULTS AND CONCLUSION: The lower healing score indicated the better healing. The score was significantly lower in the PerClot® group than in the control group (P < 0.05). No significant difference was detected between bone wax group and control group (P > 0.05). Compared with the control group, bone trabecula area was significantly increased (P < 0.05), congenital absence area was significantly reduced (P < 0.05) in the PerClot® group. In conclusion, PerClot® absorbable polysaccharide hemostats can enhance the fracture healing of the cranial bone in rabbits.

CLC Number: