Abstract:

BACKGROUND: Corneal neovascularization commonly lead to blind in China, however, which have not a patent medicine or treatment method.
OBJECTIVE: To overall understand the pathogenesis of corneal neovascularization, and to review the treatment methods for corneal vascular diseases.
METHODS: Databases of PubMed and CNKI were retrived by computer to search randomized controlled or semi-randomized controlled experiments concerning pathogenesis and treatment methods for corneal neovascularization.
RESULTS AND CONCLUSION: A total of 27 papers were included. Corneal neovascularisation, caused by corneal edema, vascular factors, inflammatory reaction, hypoxia, or corneal nerve damage, could damage visual acuity of patients. Therapies such as Avastin, Deoxyribozyme, small RNA interference, monoclonal antibody, photodynamic, and traditional Chinese Medicine have been systematic clinic or animal experiment to check their security and effectiveness. With the development of technology, corneal neovascularisation therapy would be safe and effective in future.