Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (30): 5631-5634.doi: 10.3969/j.issn.1673-8225.2010.30.029

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Histological changes in rabbit adjacent intervertebral disc following different degrees of vertebral body resection 

Zhang Liang1, Jin An-min2, Gao Liang-bin1, Li Jian1, Yang Bo1, Zhang Zhi1, Wang Le1   

  1. 1 Department of Orthopedics, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou  510150, Guangdong Province, China; 2 Orthopedics Center of Zhujiang Hospital, Southern Medical University, Guangzhou  510282, Guangdong Province, China
  • Online:2010-07-23 Published:2010-07-23
  • About author:Zhang Liang☆, Doctor, Associate chief physician, Department of Orthopedics, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou 510150, Guangdong Province, China zldxx861@sina.com
  • Supported by:

    the Medical Health Science and Technology Program of Guangzhou, No. 2009-YB-165*

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Abstract:

BACKGROUND: It remains unclear whether partial vertebral body resection affects nutrition path of intervertebral disc, thereby leading to degeneration of intervertebral disc.
OBJECTIVE: To investigate the impact of the degrees of vertebral body resection in rabbit on degeneration of adjacent intervertebral disc.
METHODS: A total of 10 New Zealand rabbits were divided into two groups according to the degrees of resection of vertebral body (1/2 and 3/4). At 6 months after operation, the intervertebral disc adjacent to the injured vertebrae and the normal intervertebral disc (normal control) were evaluated by means of hematoxylin-eosin staining to determine the number of vascular buds in Cartilage end-plate, and the changes of nucleus pulposus. The vertebral discs were also measured by alcian blue stained and calculated image optical density (IOD) to evaluate the changes of proteoglycan in nucleus pulposus.
RESULTS AND CONCLUSION: When the removal of vertebral body was less than 1/2 in anterior decompression, the nutrition condition remained unchanged, so a single segment fusion with anterior bisegment fixation should be considered. If vertebral body resection was more than 3/4, the adjacent intervertebral disc exhibited significant changes in nutritional status and lead to intervertebral disc degeneration. Therefore, double segment fusion with anterior bisegment fixation should be considered.

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