Abstract:

BACKGROUND: Functional CT technology allows morphological and functional imaging simultaneous on the same stage by the traditional CT device.
OBJECTIVE: To search a reasonable clinical method to optimize CT imaging using contrast agent bolus injection method.
METHODS: Using computer simulation technology, simulation experiment was performed using clinical CT image data from the hospital functions to study the contrast agent bolus injection method (single pulse and multiple pulse bolus injection) and the relationship between functional imaging. The simulation results were subjected to statistical error analysis to identify the best method of clinically useful contrast agent bolus.
RESULTS AND CONCLUSION: Pulse bolus injection of contrast medium was better to reduce the blood flow parameters and benefit capillary permeability surface parameters and mean transit time parameter uncertainty compared with a single bolus injection of contrast medium on the pulse. Multi-pulse group involves a two-pulse and three pulse bolus injection, in which the use of double pulse bolus injection improved the relative reference values, 36.9% blood parameters and 30% capillary surface permeability parameter respectively. Three-pulse group exhibited a certain degree of improvement in individual physiological parameters compared with double-pulse bolus injection, but the improvement is not particularly clear. Therefore, double pulse bolus injection can be used in clinical practice.