Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (29): 5483-5488.doi: 10.3969/j.issn.1673-8225.2010.29.041

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Application and progress of microencapsulation technology in medical field

Yang Xiao-yun1, Chen Er-tong1, Zhou Yan1, Liu Bao-lin 1,2, Zhang Hua1, Xu Wen-qiang1, Li Qiao-qiao1, Ye Ping1, Peng Cheng-hong 3,4,Han Bao-san 3,4
   

  1. 1 Institute of Food Science and Hypothermia, 2 Institute of Biological and Thermal Science, School of Medical Instrument and Food Engineering，University of Shanghai for Science and Technology, Shanghai  200093, China; 3 Department of General Surgery, Breast Cancer Center, Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai  200025, China; 4 Shanghai Institute of Digestive Surgery, Shanghai  200025, China
  • Online:2010-07-16 Published:2010-07-16
  • Contact: Han Bao-san, Doctor, Associate chief physician, Department of General Surgery, Breast Cancer Center, Ruijin Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai Institute of Digestive Surgery, Shanghai 200025, China hanbaosan@126.com
  • About author:Yang Xiao-yun★, Studying for master’s degree, Institute of Food Science and Hypothermia, School of Medical Instrument and Food Engineering，University of Shanghai for Science and Technology, Shanghai 200093, China
  • Supported by:

    the National High Technology Research and Development Program of China, No. 2007AA091603*, 2008AA02Z417*; Key Program of National Natural Science Foundation of China, No. 20434030*; the National Natural Science Foundation of China, No. 30801107*, 30672043*, 30772105*, 20074031*, 50776060*; Innovation Program of Shanghai Municipal Education Commission, No. 09YZ84*; Natural Science Foundation of Shanghai Municipal Science Commission, No. 07ZR14076*, 09140902300*; the Tackle Key Problems in Science and Technology of Shandong Province, No. 2008GG10002027*; Key Subject of Science Committee of Urumqi, No. y08231006*; Program for New Century Excellent Talents in University, No. 07-0559*; Shanghai Eastern Scholar Plan*

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Abstract:

BACKGROUND: The study of microcapsule attracts great attention from the medical field due to its characteristics of immunoisolation, immunoprotection, as well as the controlled release. The microcapsule has been widely used in the therapy of diabetes, Parkinson disease, hepatic failure, analgesic effect, tumor, etc.
OBJECTIVE: To summarize the characteristics of microencapsulated technology and its application in the medicine field.
METHODS: Information from PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang databases (http://www.wanfangdata.com.cn) were retrieved by the first author using key words of “microencapsulated, transplantation, controlled release” both in English and Chinese.
RESULTS AND CONCLUSION: As a kind of carrier, microcapsule supplies a three-dimensional matrix for cell culture, which could improve the intercellular effect and the function of cells; it forms an immune barrier for allogeneic cells, which prevent immunocyte from recognizing while do not affect the transportation of nutrients, oxygen and metabolites. It can treat diseases by providing the long-term stable controlled and released effective components for bodies. Although a lot of studies have reported the application of the microencapsulated technology in diabetes, Parkinson disease, hepatic failure, spinal cord injury, hypothyroidism, orthopaedics, tumor cancer and so on, clinical application remains still difficult. While expanding the application of microencapsulated technology in medical field, the ideal structure, good biocompatibility and controlled semi-permeable membrane of the microcapsule should be strengthened.

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