Abstract:

OBJECTIVE: To evaluate the properties of different occluder materials and their biocompatibility with the host, to provide reference for its clinical applications.
METHODS: Using “occluder, blocking materials, histocompatibility, blood compatibility, congenital heart disease” in Chinese and “blocking material, occluder, histocompatibility, blood compatibility, congenital heart disease” in English as the key words, a computer search was performed for relevant articles between January 2006 and March 2010. Articles related to the biocompatibility of biomaterials with the host were included; repeated study or Meta analysis articles were excluded. Totally 30 articles mainly focuses on the type, properties and application prospect of occluder materials.
RESULTS: There are many types of cardiac occluder, domestic Ampeatzer occluder has been widely used, the materials are mainly the nickel-titanium alloy, with good biocompatibility, good blocking effect and low cost, thus widely applying in clinics.
CONCLUSION: Although metal occluder has been widely used, corrosion is inevitable, thus leading to poor compatibility and surrounding tissue inflammation, resulting in disease and hemolysis or clotting phenomena. Ideal occluder material, no matter the material itself or its degradation products, can produce no inflammation and toxicity, so the occluder with good biocompatibility need to be further developed.