Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (28): 5317-5320.doi: 10.3969/j.issn.1673-8225.2010.28.045

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Association between osteocalcin Hind Ⅲ genetic polymorphism and body mass index variation
Investigation of 390 premenopausal women in Nanchang region

Xu Hong1, Yang Yu-ping2, Liu Yong-ming3, Tu Yun-ming2, Peng Jing1, Zhang Li1, Zou Lin4, Kuang Hai-bin1   

  1. 1 Department of Physiology, School of Medicine, Nanchang University, Nanchang  330006, Jiangxi Province, China; 2 Department of Nephrology and Endocrinology, The Fourth Affiliated Hospital of Nanchang University, Nanchang  330006, Jiangxi Province, China; 3 Department of Psychology, Center of Psychological Rehabilitation, Nanchang  330006, Jiangxi Province, China; 4 Department of Radioimmunology, People’s Hospital of Jiangxi Province, Nanchang  330006, Jiangxi Province, China
  • Online:2010-07-09 Published:2010-07-09
  • Contact: Kuang Hai-bin, Doctor, Associate professor, Department of Physiology, School of Medicine, Nanchang University, Nanchang 330006, Jiangxi Province, China kuanghaibin@ncu.edu.cn
  • About author:Xu Hong★, Master, Lecturer, Department of Physiology, School of Medicine, Nanchang University, Nanchang 330006, Jiangxi Province, China Hongxu1978@yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30760071*, 30960118*; Foundation of the Education Department of Jiangxi Province, No. GJJ08106*; Science and Technology Research Program of Nanchang University, No. J06*

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Abstract:

BACKGROUND: Body mass index (BMI) is a commonly used phenotype for obesity, which is determined by multiple genetic factors.
OBJECTIVE: To investigate whether osteocalcin (also known as bone Gla protein, BGP) Hind Ⅲ genetic polymorphism is associated with BMI variation.
METHODS: A total of 390 premenopausal women from a local population of Nanchang City were selected. Body weight and height were measured. All participants were genotyped at the BGP Hind Ⅲ locus using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTS AND CONCLUSION: The BGP genotype frequencies of HH, Hh and hh were 0.077, 0.408 and 0.515, respectively. The distribution of BGP Hind Ⅲ genotypes was consistent with Hardy-Weinberg equilibrium (P > 0.05). The BGP Hind Ⅲ were significantly associated with BMI (P=0.002), which could explain about 5.47% of BMI variation. On average, BMI of individuals with HH genotype was the highest [(22.81±0.73) kg/m2], individuals with Hh genotype was intermediate [(21.50±0.53) kg/m2], while individuals with hh genotype was the lowest [(20.23±0.63) kg/m2]. Therefore, carriers of HH and Hh genotypes had, respectively, approximately 12.75% and 6.28% higher BMI than carriers of the hh genotype. To our best knowledge, this is the first study reporting the association of BGP Hind Ⅲ genetic polymorphism and BMI in healthy premenopausal women.

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