Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (28): 5301-5304.doi: 10.3969/j.issn.1673-8225.2010.28.041

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Correlation between muscle segment homeobox 1 gene and non-syndromic cleft lip and palate in parts of Shanxi Province

Yin Xu-bin1, Chen Xian-jiu2, Nan Xin-rong2   

  1. 1 Stomatological College of Shanxi Medical University, Taiyuan  030001, Shanxi Province, China; 2 Department of Stomatology, First Affiliated Hospital of Shanxi Medical University, Taiyuan  030001, Shanxi Province, China
  • Online:2010-07-09 Published:2010-07-09
  • Contact: Nan Xin-rong, Master, Master’s supervisor, Professor, Chief physician, Department of Stomatology, First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China xr_nan@sina.com
  • About author:Yin Xu-bin★, Master, Stomatological College of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China woshixiaoyin@126.com
  • Supported by:

    the Science and Technology Planning Project of Taiyuan City, No. 085191*

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Abstract:

BACKGROUND: Previous studies considered that muscle segment homeobox 1 (MSX1) gene related to non-syndromic cleft lip and palate (NSCL/P). However, researches for the report on Chinese have not been seen.
OBJECTIVE: To study relevance of MSX1 gene mutation and NSCL/P pathogenesis in Shanxi province of China.
METHODS: Oral mucosa from 130 patients received treatment at the Department of Stomatology, First Affiliated Hospital of Shanxi Medical University from May 2007 to January 2008 were included, meantime, 130 normal control ones were selected. The MSX 1 gene of two groups were sequenced and compared. 
RESULTS AND CONCLUSION: The MSX 1 gene expression level was lower in the NSCL/P group than that in the control group (P < 0.01), which showed that MSX 1 gene expression level has shown a downward trend in the in the NSCL/P group. Then the MSX 1 gene products of two groups were sequenced. Logistic regression analysis showed that (AA/AT904)β=-3.74, (GG/GAA1389)β=-22.18, the variable being introduced into the equation of risk factors were AA/AT904 and GG/GAA1389, which was illustrated that in the NSCL/P patients, down-regulated expression of MSX 1 gene variants were AA/AT904 and GG/GAA1389. All results suggested that MSX 1 gene mutation at coding regions of C-terminal side of the homeodomain protein and exon 3’ end of noncoding region has correlation to NSCL/P.

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