Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (28): 5293-5296.doi: 10.3969/j.issn.1673-8225.2010.28.039

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Construction of chronic spinal cord injury models

Qian Jun1, Sun Zheng-yi2, Ma Wei-hu3   

  1. 1 Department of Orthopedics, Zhangye People’s Hospital, Zhangye  734000, Gansu Province, China; 2 Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China; 3 Department of Spine Surgery, Ningbo Sixth Hospital, Ningbo  315040, Zhejiang Province, China
  • Online:2010-07-09 Published:2010-07-09
  • About author:Qian Jun★, Master, Associate chief physician, Zhangye People’s Hospital, Zhangye 734000, Gansu Province, China qianjun0936@163.com
  • Supported by:

    the Young Science and Technology Research Fund of Gansu Province, No. 0806RJYG018*

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Abstract:

BACKGROUND: The pathology and pathophysiology of spinal cord remain poorly understood due to lack of simple and ideal animal models.
OBJECTIVE: To provide reference for the further establishment and application of chronic spinal cord injury models by comprehensive reviewing the chronic spinal cord injury models. 
METHODS: Articles published in Medline database were retrieved by computer using key words of “spinal cord injury, animal model, models, animal”. Documents with few samples or duplicated articles were excluded. Totally 34 literatures were remained for further analysis. 
RESULTS AND CONCLUSION: Animal models of spinal cord injury play an important role for exploring the etiology and pathogenesis of the spinal cord disease, especially in the neurobiology of spinal cord regeneration and evaluation of effective interventions after spinal cord injury treatments. Although the current animal models of spinal cord injury in a large variety of advantages and disadvantages of each deposit, there are many variation factors, such as individual differences among animals, the operation proficiency and the extent of damage precision device, which results in the existing models, can not accurately control the spinal cord injury in the scope and extent. Therefore, establishment of animal models of spinal cord injury with strong stability, and can reflect a specific pathological change has been a goal pursued by researchers.

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