Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (28): 5224-5227.doi: 10.3969/j.issn.1673-8225.2010.28.022

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Effects of Kangfushuang on skin radiation injury healing in rats 

Gong Zhen-yu1, Tong Ya-lin1, Wan You-hua2, Yang Run-sheng3, Su Xiao-ling3   

  1. 1 Department of Burns and Plastic Surgery, 2 Department of Pathology, 3 Experimental Animal Center, No. 181 Hospital of Chinese PLA, Guilin  541002, Guangxi Zhuang Autonomous Region, China
  • Online:2010-07-09 Published:2010-07-09
  • Contact: Tong Ya-lin, Chief physician, Professor, Department of Burns and Plastic Surgery, No. 181 Hospital of Chinese PLA, Guilin 541002, Guangxi Zhuang Autonomous Region, China
  • About author:Gong Zhen-yu★, Master, Attending physician, Department of Burns and Plastic Surgery, No. 181 Hospital of Chinese PLA, Guilin 541002, Guangxi Zhuang Autonomous Region, China gongzhenyu76@126.com
  • Supported by:

    Guangxi Natural Science Foundation, No. 2060203-255*

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Abstract:

BACKGROUND: Recombinant human epidermal growth factor (rhEGF) and povidone iodine are common used for treating radiotherapy-induced radiation skin injury, but both of the two methods have drawbacks. Kangfushuang (KFS) can promote cell proliferation and possesses antibacterial and antiphlogistic effects, which may be benefit to skin healing after radiation injury.
OBJECTIVE: To observe effects of KFS on skin radiation injury healing in rats. 
METHODS: A Wistar rat model with deep II degree burn was prepared by locally irradiating with high energy X radiation of accelerator. At 12 days after radiation, the animals with skin injury were randomly divided into KFS, rhEGF and povidone iodine groups, and treated by daily smear of drugs. The healing rate and time were observed in all the groups. The wound tissues were harvested at days 7, 14, 21 after treatment, the pathohistological changes of wound tissues, the expression of proliferating cell nuclear antigen (PCNA) were observed. The PCNA positive cells were measured by labeling index to evaluate the tissue repair in wound healing.
RESULTS AND CONCLUSION: The healing time and healing rates of the KFS group and rhEGF group were significantly better than that of the povidone iodine group (P < 0.01), but there was no significant difference between the KFS group and rhEGF group (P > 0.05). The expression of PCNA in the KFS group and rhEGF group were significantly superior to that of the povidone iodine group (P < 0.01), but there was no significant difference between the KFS group and rhEGF group (P > 0.05). The results showed that KFS can relief the early inflammatory reaction, enhance wound re-epithelization and differentiation of epidermal layers, and accelerate skin healing after radiation injury in rats.

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