Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (28): 5177-5180.doi: 10.3969/j.issn.1673-8225.2010.28.011

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Whether vitamin E supplements can decrease the risk of prostate cancer: Meta analysis

Li Jia, Hou Zhi   

  1. Department of Urinary Surgery, Affiliated Hospital of Qinghai University, Xining  810000, Qinghai Province, China
  • Online:2010-07-09 Published:2010-07-09
  • Contact: Hou Zhi, Associate chief physician, Department of Urinary Surgery, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China lijiahouzhi@163.com
  • About author:Li Jia, Attending physician, Department of Urinary Surgery, Affiliated Hospital of Qinghai University, Xining 810000, Qinghai Province, China

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Abstract:

BACKGROUND: It is poorly understood whether vitamin E supplements can decrease the risk of prostate cancer.
OBJECTIVE: To explore the relationship between vitamin E supplements and the risk of prostate cancer by Meta analysis.
METHODS: PubMed, Embase, Cochrane Library, Chinese Biomedical Literature Database, CNKI, VIP and bibliographies were retrieved to search articles containing randomized controlled trials of vitamin E supplements on risk of prostate cancer, and the data were analyzed by using RevMan5.0.
RESULTS AND CONCLUSION: A total of 5 randomized controlled trials containing 85 549 participants were included. The result of Meta analysis showed that, compared to placebo, the vitamin E supplements did not significantly affect the incidence of prostate cancer [RR=0.96, 95%CI (0.85-1.08)] and mortality [RR=0.84, 95%CI (0.57-1.24)]. Vitamin E supplements could not reduce the incidence of prostate cancer and mortality, the results still need to be confirmed by high quality, and large sample size randomized controlled trials.

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