Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (24): 4512-4515.doi: 10.3969/j.issn.1673-8225.2010.24.033

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Effects of MG29 protein on excitation-contraction coupling in senescent muscles 

Qu Hui-fang1, Pan Wen-zhao2, Yan Wan-jun3   

  1. 1 Department of Physical Education, Nanjing College of Fine Arts, Nanjing  210000, Jiangsu Province, China; 2 Langfang Vocational College, Langfang  102800, Hebei Province, China; 3 College of Sports Science, Hebei Normal University, Shijiazhuang  050016, Hebei Province, China
  • Online:2010-06-11 Published:2010-06-11
  • Contact: Yan Wan-jun, Doctor, Researcher, Master’s supervisor, College of Sports Science, Hebei Normal University, Shijiazhuang 050016, Hebei Province, China wjyan@yahoo.cn
  • About author:Qu Hui-fang, Associate professor, Department of Physical Education, Nanjing College of Fine Arts, Nanjing 210000, Jiangsu Province, China quhuifang@yahoo.cn
  • Supported by:

    the Natural Science Foundation of Education Department of Hebei Province, No. Z2009129*

Abstract:

BACKGROUND: Excitation-contraction coupling is a basic functional feature of nerve-muscle, to some extent, which closely associates with functional deterioration of senescent muscles. Researchers have made obviously progress in this field recently.
OBJECTIVE: To summarize the mechanism of the change of Ca2+ in senescent muscle cells and the effects of MG29 protein on Ca2+ changes and excitation-contraction coupling, and to provide reference for studying functional deterioration via reviewing related literatures. 
METHODS: Papers related to mechanism of the change of Ca2+ in senescent muscle cells and correlation between MG29 protein and excitation-contraction coupling published in CNKI (2000-01/2009-11) in Chinese and in PubMed (2009-01/2009-12) in English were searched by computer based on the keywords of “excitation-contraction, muscle, muscle cell, senescence, resistance training and MG29”. Obsolete, repetitive and credibility-lacking literatures were excluded.
RESULTS AND CONCLUSION: Totally 43 papers were retrieved. According to the inclusive and exclusive criteria, 9 papers were excluded and 34 documents were included in the final analysis. The results showed that MG29 plays an important function in excitation-contraction coupling and decreases with age increasing. Therefore, MG29 is speculated as a key factor of muscle senescence. Importantly, recent researches show that MG29 could be increased by resistance training.

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