Abstract:

BACKGROUND: It has been recognized that the attack of essential hypertension (EHT) is closely correlated with genetic predisposition, and polygenic inheritance is involved in this process. However, due to the first writer clinical practice of hereditary diseases in Guangdong, many hypertension family characteristics are extremely similar to autosomal dominant inheritance.
OBJECTIVE: To explore the genetic patterns of familial EHT for Guangdong Han population.
METHODS: Using familialanalysis, the “Smith” agonic revise method and multifactorial inheritance tests, the genetic patterns of 24-88-year-old EHT patients with family history in four affiliated hospitals and eight county hospitals in Guangdong region was studied.
RESULTS AND CONCLUSION: In 215 core family of 1326 people in the survey, a total of 914 people were compatriots on both sides (483 males and 431 females), contained 442 patients (230 males and 212 females). The prevalence of relatives was 442/914 = 0.483 6, which was closed to the theoretical value of 0.5 of autosomal dominant inheritance (P > 0.05). The prevalence rate of male was 230/442 = 0.520 4, and the prevalence rate of female was 212/442 = 0.479 6. It was accordance with the inspection by x2fits autosomal dominant inheritance onset of equality of opportunity between men and women of the theoretical assumptions. The genetic hypertension of 211 core pedigree of 215 core families supported autosomal dominant inheritance. By tests for multifactorial inheritance, the observed value of the familial EHT pedigrees in our study was 63.63, closest to the expected value of 65.79 of autosomal dominant, but far from the expectations of 11.47. The multiple genes analysis revealed that the way of familial genetic EHT supported autosomal dominant inheritance and recessive transmission. The results demonstrated that a family EHT genetic patient was early prediction of high-risk population of EHT, which should pay more attention.