Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (15): 2823-2827.doi: 10.3969/j.issn.1673-8225.2010.15.039

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MtDNA variants, apolipoprotein E gene and longevity in Southern Chinese population

Feng Jie 1,2, Liu Ming 1,2, Zhang Jian-yi2, Wan Gang2, Qi Ke-yan2, Zheng Chen-guang3, Lü Ze-ping3, Hu Cai-you3, Yang Ze2   

  1. 1 Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing   100730, China; 2 Key Laboratory of Geriatrics, National Institutes of Geriatrics, Beijing Hospital, Ministry of Health, Beijing   100730, China; 3 Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning   530012, Guangxi Zhuang Autonomous Region, China
  • Online:2010-04-09 Published:2010-04-09
  • Contact: Yang Ze, Doctor, Professor, Key Laboratory of Geriatrics, National Institutes of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China yangze016@ yahoo.com.cn
  • About author:Feng Jie☆, Studying for doctorate, Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China; Key Laboratory of Geriatrics, National Institutes of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China fj79330@yahoo.com.cn
  • Supported by:

    the Grant from the Department of Science and Technology of Guangxi Zhuang Autonomous Region of China, No. Guikezi 0848016*

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Abstract:

BACKGROUND: MtDNA haplogroup D has been shown to influence longevity trait. However, the effects that mtDNA haplogroup D (and its subhaplogroups) have upon longevity in Southern Chinese population have rarely been reported, and the effect of reaction of mtDNA haplogroup D (and its subhaplogroup) and apolipoprotein E (APOE) gene on longevity remains poorly understood.
OBJECTIVE: To explore the association between mtDNA haplogroup D (and its subhaplogroup) and longevity in southern Chinese population, and the interaction of mtDNA haplogroup D (and its subhaplogroup) with APOE gene.
METHODS: A total of 1 038 people were selected from Bama, Guangxi between 2007 and 2008, including 367 long-lived individuals (aged > 90 years) and 671 local and unrelated younger controls (aged 40-60 years). Using polymerase chain reaction-restriction fragment length polymorphism, the distribution of mtDNA haplogroup D and its subhaplogroup (D4, D4a) was tested. The confounding effect of gender and APOE gene was detected by stratification analysis.
RESULTS AND CONCLUSION: There was no significant correlation between mtDNA haplogroup D (and its subhaplogroup) and longevity (P > 0.05). Stratification analysis by gender showed no significant difference for frequencies distribution of mtDNA haplogroup D and its subhaplogroup (D4, D4a) between long-lived individuals and controls in women and men (P > 0.05). However, the frequency distribution of mtDNA haplogroups D was different between long-lived individuals and controls with APOE ε4 carriers (P < 0.05) through stratification analysis by APOE gene. Results show that mDNA haplogroup D may affect longevity by interacting with APOE gene.

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