Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (15): 2810-2813.doi: 10.3969/j.issn.1673-8225.2010.15.036

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Role of ciliary neurotrophic factor on nerve rehabilitation following nerve injury                               

Zhang Wei1, Hong Xiong2, Peng Zhong-juan3   

  1. 1 Department of Physical Education, Jiangxi University of Traditional Chinese Medicine, Nanchang  330004, Jiangxi Province, China;     2 Institute of Physical Education, Jiangxi Normal University, Nanchang  330027, Jiangxi Province, China; 3 Department of Postgraduate, Jiangxi University of Traditional Chinese Medicine,  Nanchang  330004, Jiangxi Province, China
  • Online:2010-04-09 Published:2010-04-09
  • About author:Zhang Wei★, Master, Associate professor, Department of Physical Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China jxzw666@163.com

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Abstract:

BACKGROUND: Ciliary neurotrophic factor (CNTF) is widely distributed in neuronal system, which has nutritional function.
OBJECTIVE: To summarize the position and application prospect of CNTF on neural injury and reparation in China and abroad.
METHODS: Computer-based online search of Chinese Full Text Databases (website: http://dlib.cnki.net/kns50/index.aspx) and PubMed databases (website: http://www. ncbi.nlm.nih.gov/pubmed/) was performed with key words of “Ciliary neurotrophic factor, Nerve injure” from January 1990 to June 2009. Research concerning research status and development of CNTF was selected, including changes of CNTF following nerve injury; the repair mechanism and protection of CNTF on neurons; regulation on reparative process; the recovery of axoplasmic transport function of axoplasm, as well as the regeneration on injured nerves. The repeated research or Meta analysis was excluded. 
RESULTS AND CONCLUSION: CNTF had trophic action and was widely distributed in nervous system. The source of endogenous CNTF was autocrine of Schwann cells, glial cells and neurons. In the repair process of nerve injury, CNTF protected and repaired the injured nerves via various ways, such as regulated related enzyme expression, boost JAK-STAT to promote production of GAP-associated protein GAP and molecular, advance axoplasmic transport and restore, and promote neural restore by enhancing Schwann corpuscular vegetation variation. CNTF plays an important role in the recovery of injured nerves. Studies regarding the effects of CNTF on neural injuries are providing a basis for its clinical application.

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