Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (15): 2744-2747.doi: 10.3969/j.issn.1673-8225.2010.15.020

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Role of local biomechanical factors in pathogenesis of L5/S1 disc herniation

Dong Zhen-hui1, Wang De-chun1, Li Meng-zhen2   

  1. 1 Department of Spine Surgery, Affiliated Hospital of Qingdao University Medical College, Qingdao  266003, Shandong Province, China; 2 Department of Orthopedics, Traditional Chinese Medicine Hospital of Juxian City, Rizhao  276500, Shandong Province, China
  • Online:2010-04-09 Published:2010-04-09
  • Contact: Wang De-chun, Doctor, Chief physician, Professor, Department of Spinal Surgery, Affiliated Hospital of Medical College of Oingdao University, Qingdao 266003, Shandong Province, China dechun-w@163.com
  • About author:Dong Zhen-hui★, Studying for master’s degree, Department of Spinal Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China donghui0801@gmail.com

Abstract:

BACKGROUND: The relationship between biomechanical factors and low back pain has been extensively studied in recent years, but mostly focus on unitary biomechanics characters and low back pain. There are few studies with regard to partial biomechanical factors and L5/S1 disc herniation.
OBJECTIVE: To explore the role of biomechanical factors in pathogenesis of L5/S1 disc herniation. 
METHODS: Totally 124 cases were included in the study. All cases were divided into the disc herniation group and control groups, with 62 cases in each group. The disc herniation group consisted of L5/S1 herniation patients received treatment at the Affiliated Hospital of Medical College of Oingdao University, and the healthy examination cases were served as controls. The indicator included relative depth of lumbar 5 vertebra, lumbosacral transitional vertebra, relative height of L5/S1 disc, lumbosacral angle, sacral horizon angle and sacral Inclination angle. The difference of the indicators between the two groups was analyzed statistically. 
RESULTS AND CONCLUSION: The relative depth of L5 vertebra of the disc heniation group was significantly higher than the control group (P < 0.01), and the number of lumbosacral transitional vertebra of disc heniation group was significantly fewer than the control group (P < 0.01), which indicated that the deep-seated lumbar 5 vertebra and lumbosacral transitional vertebra might protect L5/S1 disc and reduce the incidence of L5/S1 disc herniation. Lumbosacral angle and sacral horizon angle of disc herniation group were significantly lower than that of control group (P < 0.01), but there was no significant statistical sense in the difference of sacral inclination angle between the two groups (P > 0.05), and there was no significant statistical sense in the difference of relative height of L5/S1 disc (P > 0.05), which indicated the roles of relative height of L5/S1 disc, lumbosacral angle, sacral horizon angle and sacral inclination angle in L5/S1 disc herniation still need further study.

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