Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (13): 2399-2402.doi: 10.3969/j.issn.1673-8225.2010.13.030

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Th1/Th2 immunological response expression in a patient of coronary arterial stent restenosis

Lin Jin-zhao1, Zhang Jun2   

  1. 1 Department of Cardiology, First Hospital Affiliated to Liaoning Medical University, Jinzhou 121000, Liaoning Province, China; 2 Department of Oral Medicine, Second Hospital Affiliated to Liaoning Medical University, Jinzhou   121000, Liaoning Province, China
  • Online:2010-03-26 Published:2010-03-26
  • Contact: Zhang Jun, Doctor, Department of Oral Medicine, Second Hospital Affiliated to Liaoning Medical University, Jinzhou 121000, Liaoning Province, China cncnlady@126.com
  • About author:Li Jin-zhao☆, Doctor, Associate chief physician, Department of Cardiology, First Hospital Affiliated to Liaoning Medical University, Jinzhou 121000, Liaoning Province, China medicaldoctor33@sina.com
  • Supported by:

    the Foundation of Education Department of Liaoning Province, No. 30556013*

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Abstract:

BACKGROUND: Mechanism of restenosis remains unclear. Inflammatory unbalance plays an important role in various diseases, being related to stent restenosis.
OBJECTIVE: To evaluate the distribution characteristics of Th1-type cytokines [interferon-γ (INF-r) and interleukin-2 (IL-2)] and Th2-type cytokines (IL-4 and IL-10) in the serum of the patients with the in-stent restenosis following coronary artery stent implantation.
METHODS: The concentrations of INF-γ, IL-2, IL-4, and IL-10 in the serum of 32 patients with in-stent restenosis following coronary artery implantation (experimental 2 group) were measured with enzyme linked immuno-sorbent assay (ELISA). The serum levels of the four cytokines were compared with the subjects without stent implantation and coronary artery disease (n=30, control I group), the patients without stent implantation but with the coronary artery disease (n=30, control II group), and the patients with stent implantation but without in-stent restenosis (n=30, experimental I group).
RESULTS AND CONCLUSION: There was no significant difference in the level of the INF-γ, IL-2, IL-4, and IL-10 between control 2 group and control 1 group (P > 0.05); while there was also no significant difference in those levels between experimental 1 group and control 1 group (P > 0.05). The levels of INF-γ and IL-2 in the experimental 2 group were significantly higher than other three groups (P < 0.01); but the levels of IL-4 and IL-10 in the experimental 2 group were significantly lower than control 1 and experimental 1 groups (P < 0.01). The results demonstrated that Th1 and Th2 inflammatory unbalances, i.e., up-regulation of Th1 and down-regulation of Th2, occurred in patients with in-stent restenosis, which might be the key factors for in-stent restenosis following coronary artery implantation.

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