Chinese Journal of Tissue Engineering Research ›› 2025, Vol. 29 ›› Issue (15): 3290-3300.doi: 10.12307/2025.182

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Visual analysis of research trends in pigmented villonodular synovitis

Xiong Binglang1, Cao Xuhan1, Zhang Cheng2, Guo Ziyan1, Sun Xudong1, Bai Zixing3, Sun Weidong1   

  1. 1Second Department of Bone and Joint, 2Third Department of Bone and Joint, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100015, China; 3Department of Orthopedics and Traumatology, Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital, Beijing 101300, China
  • Received:2024-04-18 Accepted:2024-05-25 Online:2025-05-28 Published:2024-11-06
  • Contact: Sun Weidong, MD, Chief physician, Second Department of Bone and Joint, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100015, China
  • About author:Xiong Binglang, Doctoral candidate, Second Department of Bone and Joint, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100015, China
  • Supported by:
    National Natural Science Foundation of China (General Program), No. 81373802 (to SWD); Beijing Municipal Clinical Characteristic Applied Research Project, No. Z191100006619024 (to SWD); Special Project of Traditional Chinese Medicine Clinical Evidence-based Research in the High-level Traditional Chinese Medicine Hospital Construction Project of Wangjing Hospital of China Academy of Chinese Medical Sciences, No. WJYY-XZKT-2023-18 (to SWD)

Abstract: BACKGROUND: There are still great controversies in the etiology, clinical manifestations, diagnosis and treatment of pigmented villonodular synovitis. Bibliometric and visualization studies on pigmented villonodular synovitis can clarify the research development context and point out the direction for future research. 
OBJECTIVE: To analyze the global research status, hotspot, and trend of pigmented villonodular synovitis. 
METHODS: All publications related to pigmented villonodular synovitis from 1995 to 2023 were retrieved from Web of Science and CNKI. Citespace and bibliometrics were used to analyze the clustering, co-occurrence, and emergent words of all articles. The Web of Science database adopts subject headings plus free words for retrieval, while the CNKI database retrieves through subject headings. Finally, 986 English articles and 599 Chinese articles were included.
RESULTS AND CONCLUSION: (1) The United States has an absolute leading position in research in this field, ranking first in the number of published papers, H index, and cited times. China ranks the 4th in the total volume of published articles and 12th in the H index. The quality of published articles and international cooperation still need to be improved. (2) Cluster analysis of pigmented villonodular synovitis studies showed that the top five clusters were radiotherapy, soft tissue sarcoma, rheumatoid arthritis, magnetic resonance imaging, and diagnosis. (3) The key words that continued to emerge until 2023 were colony-stimulating factor 1, giant cell tumor of tendon sheath, case report, chromosome translocation, radiotherapy, expression, and kinase. (4) Based on keyword analysis and co-citation analysis, it is found that the research on the clinical characteristics of pigmented villonodular synovitis, the development of new colony-stimulating factor 1 inhibitors, and the application of colony-stimulating factor 1 inhibitors in the treatment process are current research hotspots. (5) Combining thematic evolution with the analysis of current research hotspots, based on clarifying the etiology, pathogenesis, and clinical characteristics of pigmented villonodular synovitis, improving the diagnostic accuracy of pigmented villonodular synovitis, enhancing the precision of treatment, and reducing the recurrence rate after treatment will be key issues that require focus in the future.

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程

Key words: bibliometrics, visualization, Citespace, pigmented villonodular synovitis, document clustering analysis, co-occurrence analysis, joint, hot spots

CLC Number: