Progress and challenges of bone tissue engineering scaffolds

doi:10.12307/2021.072

Abstract

Abstract: BACKGROUND: Bone tissue engineering scaffolds are considered as a potential alternative to traditional bone grafting due to their unlimited supply and lack of disease transmission. However, bone tissue engineering scaffolds have not entered clinical practice due to some limitations or challenges.
OBJECTIVE: To discuss the clinical and mechanical requirements of bone scaffolds, summarize the biomaterials used in various scaffolds and the challenges and future trends in the field of bone tissue engineering scaffolds.
METHODS: Search words were “bone tissue engineering, bone scaffolding, biomaterials, bone histology, bone defect, bone repair” in English and Chinese. Relevant literature on bone tissue engineering scaffolds published from 2005 to 2020 was searched by computer in CNKI, Wanfang database, and PubMed database. Systematic summary, summary and analysis were conducted to comprehensively describe the new progress and challenges in the research on bone tissue engineering scaffolds.
RESULTS AND CONCLUSION: At present, natural derived biomaterials, synthetic biomaterials and metal materials are mainly used in the preparation of bone tissue engineering scaffolds. These materials have been used in the manufacture of bionic scaffolds to support the growth and regeneration of bone tissue. Although great progress has been made in the research of scaffold materials for bone tissue engineering, there are still many key obstacles to be cleared for the real application of bone tissue engineering in clinical practice. The future research focus is to find some materials similar to human autogenous bone tissue structure and performance, and carry out bionic design on them, so as to develop tissue engineered artificial bone similar to human autogenous bone structure and performance.

Key words: bone, materials, bone tissue engineering, scaffold materials, bone defects, bone repair, bone histology, clinical requirements, hydroxyapatite, collagen, review

CLC Number:

Liao Xinyu, Wang Fuke, Wang Guoliang. Progress and challenges of bone tissue engineering scaffolds[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(28): 4553-4560.

Figures/Tables 2

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