Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (30): 5689-5692.doi: 10.3969/j.issn.1673-8225.2011.30.043

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Delayed union and nonunion associated with obstructive sleep apnea

Zhang Jian-guo1, Wang Dong1, Song Lu2    

  1. 1Department of Orthopedics, 2Department of Respiration, the Second Hospital of Shanxi Medical University, Taiyuan  030001, Shanxi Province, China
  • Received:2011-01-30 Revised:2011-03-16 Online:2011-07-23 Published:2011-07-23
  • Contact: Wang Dong, Ph.D., Professor, Doctoral supervisor, Department of Orthopedics, the Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • About author:Zhang Jian-guo★, Studying for master’s degree, Department of Orthopedics, the Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China z_j_g886@163.com

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Abstract:

BACKGROUND: Obstructive sleep apnea (OSA) can affect the expression of regulatory proteins associated with bone and/or osteoclasts and bone healing, so the factures are difficult to heal and even aggravated.
OBJECTIVE: To observe the association of OSA and nonunion.
METHODS: Randomly selected in our hospital from June 2005 to June 2010 were 338 cases of fractures, of which 228 were patients with bone healing and 110 were patients with nonunion (11 cases combined with OSA confirmed by a portable sleep screening instrument). Monitoring data and relevant clinical data were analyzed.
RESULTS AND CONCLUSION: Compared to patients with bone healing, OSA prevalence was higher in nonunion patients (P < 0.05), odds ratio(OR)=2.422, 95% confidence index (CI)=0.996-5.891; in the nonunion with OSA group, the healing time was correlated negatively with minimum oxygen saturation during the night (LSaO2) and average oxygen saturation (MSaO2) (r=0.40, 0.38, P < 0.05), and the X-callus score was correlated positively with LSaO2 and MSaO2 (r=0.34, 0.47, P < 0.05).OSA may be the new risk factors of nonunion.

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