Abstract:

BACKGROUND: The evaluation of biomaterial biocompatibility is a key step before the clinical application, but the current international standard evaluation system has not been completely established, which affected the research of biomaterials.
OBJECTIVE: To review and prospect the evaluation method of biomaterials on biocompatibility.
METHODS: “Biomaterials, biocompatibility, evaluated methods, trend” in English was utilized as search terms to retrieve PubMed database (2000-01/2010-08). Literatures were limited to English. Simultaneously, “biomaterials, biocompatibility, evaluated methods, trend” in Chinese was used to search CNKI database. Literatures were limited to Chinese. A total of 104 literatures were retrieved, and finally 5 standard literatures were included.
RESULTS AND CONCLUSION: Biomaterials must have a good biocompatibility to ensure security of clinical application. Biomaterials does not cause clinical reaction and can tolerate the role of the host systems to remain relative stable, no destruction, and exclusion of the biological properties, which was a good biocompatibility. The evaluated method of biocompatibility of biomaterials is an indispensable key before clinical experiment. With the rapid development of molecular biology, the evaluated methods of biocompatibility of biomaterials have been more and more diversification and their evaluation have been raised from the cell level to molecular level.