Abstract:

OBJECTIVE: To investigate the biological materials intervention for wrist cartilage injury, and to choose an ideal biomaterial for trauma repair and functional reconstruction of wrist articular cartilage injury.
METHODS: A computer search was performed on PubMed database (PubMed: 1996/2010) and Chinese Academic Journal Full-text database (CNKI: 1996/2010), using “Wrist Joint, Cartilage, Injury, Rehabilitation, Treatment” in English or in Chinese as key words for the title and summary. Articles published in non-core journals were excluded, a total of 25 articles related to the wrist articular cartilage injury and biological materials on the repair of wrist cartilage injury were selected.
RESULTS: The arthroscopic microfracture technique combined hyaluronic acid gel can significantly improve the thickness of regenerated cartilage, make it closer to hyaline cartilage. Calcium polyphosphate fiber/gelatin scaffold composite material can basically meet the porosity requirements for tissue engineering scaffold composite materials. Autogenous periosteal transplantation and fixation of bone marrow mesenchymal stem cells can promote articular cartilage repair, generate adaptive cartilage, and transforming growth factor β1 induces bone marrow mesenchymal stem cells differentiate into chondrocytes.
CONCLUSION: Because of wrist joint anatomical structure and biomechanical complexity, wrist cartilage injury is common, tissue-engineered cartilage repair can repair trauma and reconstruct function through the cells and scaffold composite implanted into damaged tissue or organ, so as to provide an effective way for the wrist joint cartilage injury repair. Stem cells induction and transforming growth factor β1 gene modification can provide new research directions for wrist cartilage repair.