Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (33): 6267-6270.doi: 10.3969/j.issn.1673-8225.2010.33.045

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Correlating estrogen receptor-alpha PvuII genetic polymorphism with bone mass index in premenopausal Han Chinese women from Nanchang region

Xu Hong1, Peng Jing1, Zhang Li1, Zou Lin2, Kuang Hai-bin1   

  1. 1 Department of Physiology, School of Medicine, Nanchang University, Nanchang   330006, Jiangxi Province, China;2 Department of Radioimmunology, People's Hospital of Jiangxi Province, Nanchang  330006, Jiangxi Province, China
  • Online:2010-08-13 Published:2010-08-13
  • Contact: Kuang Hai-bin, Doctor, Associate professor, Department of Physiology, School of Medicine, Nanchang University, Nanchang 330006, Jiangxi Province, China khb9909@yahoo.com.cn
  • About author:Xu Hong★, Master, Lecturer, Department of Physiology, School of Medicine, Nanchang University, Nanchang 330006, Jiangxi Province, China hongxu1978@ yahoo.com.cn
  • Supported by:

    the National Natural Science Foundation of China, No. 30760071*, 30960118*; A Grant from Education Department of Jiangxi Province, No. GJJ08106*; Scientific Research Foundation of Nanchang University, No.J06*

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Abstract:

BACKGROUND: Obesity is serious complex disease determined by multiple genetic factors. Body mass index (BMI) is a common phenotype for obesity. Although some candidate genes have been shown to be related with BMI variation, the underlying substantial relationship remains poorly understood.
OBJECTIVE: To investigate whether estrogen receptor-α (ER-α) PvuII genetic polymorphism is associated with BMI variation.
METHODS: In total 390 premenopausal women from a local population of Nanchang City in Jiangxi Province People's Hospital. Body weight and height were measured. All participants were genotyped at the ER-α PvuII locus using polymerase chain reaction-restriction fragment length polymorphism.
RESULTS AND CONCLUSION: The ER-α PvuII genotype frequencies of PP, Pp and pp were 0.133, 0.485 and 0.382, respectively. The distribution of ER-PvuII genotypes was in accordance with Hardy-Weinberg equilibrium (HWE) (P > 0.05). There was no significant correlation between ER-α PvuII genetic polymorphism and BMI variation (P = 0.338). These findings indicate that ER-α PvuII genetic polymorphism does not greatly affect BMI variation of premenopausal women in Nanchang region.

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