Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (26): 4907-4910.doi: 10.3969/j.issn.1673-8225.2011.26.039

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Vitamin D deficiency in winter related to bone loss of older people in northern China  

Zhou Bo1, Wang Xiao-hong1, Guo Lian-ying1, Xu Chao1, Zhang Zhuo1, Kan Zhi-ying2   

  1. 1The Department of Nutrition and Food Hygiene, Shenyang Medical College, Shenyang  110034, Liaoning Province, China
    2Northeastern University Hospital, Shenyang  110004, Liaoning Province, China
  • Received:2011-03-15 Revised:2011-04-16 Online:2011-06-25 Published:2011-06-25
  • About author:Zhou Bo☆, Doctor, Professor, the Department of Nutrition and Food Hygiene, Shenyang Medical College, Shenyang 110034, Liaoning Province, China zhoubo63@hotmail.com
  • Supported by:

    Nestle Nutrition Fund, No. 200012*; Science Research Program of Higher Education, Liaoning Education Bureau, No. 20391148*

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Abstract:

BACKGROUND: There are seasonal variations in vitamin D status of older people in northern China. Vitamin D status of older people is deficient in winter and spring.
OBJECTIVE: To evaluate the effect of vitamin D deficiency in winter on bone loss in elderly people in Shenyang.
METHODS: 100 healthy Han volunteers over 60 years old living in Shenyang were selected. Plasma 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), osteocalcin, calcium and phosphate, overnight fasting urine free deoxypyridinoline, calcium, phosphate and creatinine were analyzed in March 2000. Hip bone mineral density (BMD) was measured in March 2000 and in March 2005.
RESULTS AND CONCLUSION: At baseline, mean plasma 25(OH)D concentration was (31.0±12.3) nmol/L; 25(OH)D concentration of 40% of subjects was < 25 nmol/L; mean PTH was (29.4±11.5) ng/L for all subjects and (34.6 ± 13.5) ng/L for the subjects with 25(OH)D concentration < 25 nmol/L; plasma 25(OH)D concentration was correlated negatively with PTH concentration (r=-0.479, P < 0.000 1). After 5 years, mean bone loss rate was (3.05±4.07)% at the femoral neck and (1.46±5.02)% at the trochanter. Bone loss rate at femoral neck was negatively correlated with plasma 25(OH)D concentration at baseline (r=-2.3, P=0.02) after adjustment for weight, height and age. Bone loss rate at femoral neck for the subjects with plasma 25(OH)D concentration < 25nmol/L was 103% higher than that of the subjects with plasma 25(OH)D concentrations > 25 nmol/L (F=7.206 2, P=0.008 5). No correlation was found between other markers and bone loss rate. In older populations who generally have a low vitamin D status, vitamin D deficiency is negatively contributed to their bone loss.    

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