Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4511-4515.doi: 10.3969/j.issn.1673-8225.2011.24.035

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Genetic variations of bone morphogenetic protein 7 associated with obesity in Xinjiang Uygur populations

Yan Zhi-tao1, Li Nan-fang2, Guo Yan-ying2, Yao Xiao-guang2, Wang Hong-mei2, Hu Jun-li2   

  1. 1Xinjiang Medical University Xinjiang Postgraduate College, Urumqi  830000, Xinjiang Uygur Autonomous Region, China
    2Department of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Research Center of Diagnosis and Treatment of Hypertension, Urumqi  830000, Xinjiang Uygur Autonomous Region, China
  • Received:2011-03-25 Revised:2011-05-03 Online:2011-06-11 Published:2011-06-11
  • Contact: Li Nan-fang, Doctor, Chief physician, Professor, Doctoral supervisor, Department of Hypertension of the People's Hospital of Xinjiang Uygur Autonomous Region, Research Center of Diagnosis and Treatment of Hypertension, Urumqi 830000, Xinjiang Uygur Autonomous Region, China lnanfang2009@hotmail.com
  • About author:Yan Zhi-tao☆, Studying for doctorate, Attending physician, Xianjiang Medical University Postgraduate College, Urumqi 830000, Xinjiang Uygur Autonomous Region, China greenbloodsword@yahoo.com.cn
  • Supported by:

    the Open Topic of the Key Laboratory of Hypertension in Xinjiang Uygur Autonomous Region, No. XJYS0906- 2009-03*; the Youth Foundation Program of People’s Hospital of Xinjiang Uygur Autonomous Region, No. 20090204*

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Abstract:

BACKGROUND: Studies show that bone morphogenetic protein 7 (BMP-7) gene maps to chromosome 20q13, a susceptibility locus for obesity. BMP-7 represents a strong biological and positional candidate for a susceptibility factor for obesity.
OBJECTIVE: To investigate the association between the genetic variations of functional region in BMP-7 gene and obesity in Xinjiang Uygur populations.
METHODS: A case-control study was conducted based on epidemiological investigation. 1063 Uygur populations were selected. The exons, segmental introns and the promoter regions of BMP-7 gene were sequenced in 48 Uygur obese patients (male/female: 24/24). Representative variations were selected according to the minor allele frequency and linkage disequilibrium and genotyped using the TaqMan polymerase chain reaction method in 1063 Uygur individuals, a relatively isolated general population in a relatively homogeneous environment and a case-control study was conducted to analyze the association between genetic variations of BMP-7 gene and obesity.
RSSULTS AND CONCLUSION: Five novel and eight known variations in the BMP-7 gene were identified. Two genotype distributions, rs60254222 and rs17480735, followed Hardy-Weinberg equilibrium. There were significant differences in AA, AG, GG genotype distribution frequency of rs6025422 variation between obese and control groups in old adults (32.2%, 55.7%, 12.2% vs. 23.8%, 48.3%, 27.9%; P < 0.01)．There were significant differences in means of body mass index, waist circumference and waist-to-hip ratio were significantly decreased among individuals with AA, AG and GG genotypes of rs60254222 in old adults (P < 0.05). Logistic regression analysis showed that GG genotype of rs60254222 variation might be a obesity protective factor in old adults (OR = 0.578, 95% confidence interval 0.401-0.833, P = 0.003). Results showed that rs60254222 polymorphism in BMP-7 gene may be associated with obesity in Uygur populations.

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