Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4537-4540.doi: 10.3969/j.issn.1673-8225.2011.24.041

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Relationship of transforming growth factor beta 1 with bone turnover markers and bone mineral density

Pi Yin-zhen1, Liao Er-yuan2   

  1. 1Department of Endocrinology, the First Hospital of Changsha, Changsha  410006, Hunan Province, China
    2Institute of Metabolism and Endocrinology, Second Xiangya Hospital of Central South University, Changsha  410011, Hunan Province, China
  • Received:2010-12-08 Revised:2011-01-10 Online:2011-06-11 Published:2011-06-11
  • Contact: Liao Er-yuan, Doctor, Professor, Doctoral supervisor, Institute of Metabolism and Endocrinology, Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China eyliao1207@21.cn. com
  • About author:Pi Yin-zhen★, Master, Associate chief physician, Department of Endocrinology, the First Hospital of Changsha, Changsha 410006, Hunan Province, China yinzhenpi@126.com
  • Supported by:

    the Key Clinical Project of Chinese Ministry of Health, No. 2001035427*

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Abstract:

BACKGROUND: Transforming growth factor-β1(TGF-β1) is an important cytokine in the regulation of bone remodeling. Whether it can be used as a sensitive marker to bone turnover is incompletely understood.
OBJECTIVE: To investigate the relationship of TGF-β1 with bone formation and resorption markers, and bone mineral density (BMD) at the anteroposterior lumbar spine.
METHODS: Totally 663 healthy women from Changsha were analyzed, aged 20-80 years. Levels of TGF-β1, serum bone alkaline phosphatase (sBAP) and serum C-terminal cross-linked telopeptides (sCTx) were measured by ELISA, at the same time, the BMD of anteroposterior lumbar spine was measured by dual-energy x-ray absorptiometry. The associations between TGF-β1 and other indexes were analyzed.  
RESULTS AND CONCLUSION: The TGF-β1 levels reached a peak in the 30-39 and 40-49 years groups, which had a negative correlation with age, but no correlation with body mass index (BMI). After corrected for BMI, TGF-β1 was negatively correlated to sBAP and sCTx, but was positively correlated with BMD of spine after correction of BMI or age. TGF-β1 can act as a sensitive cytokine to reflect the changes of bone turnover.

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