Abstract:

OBJECTIVE: To evaluate the types and characteristics of existing nanometer artificial skin and materials, as well as the application and development prospects in burn wounds.
METHODS: A computer search was performed in Wanfang database (http://www.wanfangdata.com.cn/) between January 1999 and December 2009 to retrieve articles of nanometer artificial skin and materials applied in burn wound, using key words of “nanotechnology, artificial materials, burn wound” in Chinese. After the repeated study, general review or Meta analysis were excluded, 24 articles were screened into the evaluation.
RESULTS: At present, nano-dressings for skin repair are mainly keratinocyte growth factor, bacterial cellulose, nano-silver and chitosan nano-particles, etc. According to the principles of size effect and surface effect, a variety of nanometer skin dressings can achieve better adhesion, effectively prevent the bleeding wound and infection, reduce pain, and accelerate wound healing. Nano-silver is most used in clinical application and fastest growing. Nano-silver compound with other materials is also under exploring ways and has obtained some success. Meanwhile, a series of problems regarding nano-materials repair burn wound, such as security, stability, uniformity and productivity, are also paid attention, it is one of the current hotspot of related studies.
CONCLUSION: The nanometer dressing, with various types, good efficacy and low adverse events, is an ideal medication type of burn wounds, being worth further study.