Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (29): 5360-5362.doi: 10.3969/j.issn.1673-8225.2010.29.010

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Preparation and biological degradation of chitosan tube stent

Li Ya-xun1, Chen Gang2, Shi Wen-jun2   

  1. 1 Department of General Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou  121001, Liaoning Province, China; 2 Department of Thoracic Surgery, Second Affiliated Hospital of Chinese Medical University, Shenyang  110003, Liaoning Province, China
  • Online:2010-07-16 Published:2010-07-16
  • About author:Li Ya-xun★, Master, Associate chief physician, Department of General Surgery, First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China xy7224@sina.com
  • Supported by:

    the Subject of Ministry of Health, No. WKZ-2000-1-17*

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Abstract:

BACKGROUND: Our previous studies have demonstrated that rejection and long-term complication occur in repairing esophagus defects using ilica gel or metal stents. Chitosan stent is prepared in order to find an ideal biological degradation stent and to observe its in vivo compatibility and degradation.
OBJECTIVE: To explore the preparative method and biology characters of chitosan stents.
METHODS: Initially, acetic acid solution was added into chitosan to get 60 g/L chitosan acetic acid hydrosol, and then, the tube was prepared by membrane making way and the chitosan was took off in sodium hydroxide. The tube with 5-mm inside diameter was cut into a 2-mm length segment and implanted into rats. Gross observation and light microscope were used to observe compatibility and degradation of chitosan tube.
RESULTS AND CONCLUSION: The chitosan tube presented with smooth surface and good tenacity, which could be soften after absorbing water. The tube could be absorbed and degraded by tissues with time prolonged. It gives a new kind of way to prepare chitosan tube and approves the biological degradation.

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