Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4405-4408.doi: 10.3969/j.issn.1673-8225.2011.24.009

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Construction of rabbit models with thigh soft tissue injury and repair effect of traditional Chinese medicine Diechuangsan 

Zhang Gui-fu1, Wang Zhi-yi2, Liu Dan-ping3   

  1. 1Postgraduate College of Liaoning Medical University, Jinzhou  121001, Liaoning Province, China
    2Jinzhou Petrochemical Hospital, Jinzhou  121001, Liaoning Province, China
    3Department of Orthopedics, First Affiliated Hospital of Liaoning Medical University, Jinzhou  121001, Liaoning Province, China
  • Received:2010-12-06 Revised:2011-02-03 Online:2011-06-11 Published:2011-06-11
  • Contact: Wang Zhi-yi, Master, Chief physician, Jinzhou Petrochemical Hospital, Jinzhou 121001, Liaoning Province, China shanghaitanxu@qq. com
  • About author:Zhang Gui-fu★, Studying for master’s degree, Physician, Post graduate College of Liaoning Medical University, Jinzhou 121001, Liaoning Province, China

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Abstract:

BACKGROUND: Traditional Chinese medicine Rheum palmatum L. and Cortex Phellodendri Chinensis have the property of activating blood circulation and removing stasis, as well as deswelling and alleviating pain, which obtain good outcomes in treating soft tissue injury.
OBJECTIVE: To study the effect of Diechuangsan (DCS) on experimental soft tissue injury and prostaglandin E2 expression.
METHODS: Totally 36 New Zealand big ear white rabbits were randomly divided into 3 groups, namely, DCS, model and control groups. Rabbits were established acute soft tissue injury models and treated by DCS at 30 minutes after model preparation, once per day. No medication was performed in the model and control groups. Prostaglandin E2 expression and hemorheology index changes were observed at 5 days after model preparation. The recovery of injured soft tissues was observed by hematoxylin-eosin staining and pathological score at 5 and 13 days after model preparation.
RESULTS AND CONCLUSION: Compared with the model group, the pathological score of the DCS group was higher (P < 0.05), which was earlier close to the normal tissues. In addition, the prostaglandin E2 expression and blood viscosity of the DCS group was lower than that of the model group (P < 0.05). It is suggested that DCS can repair injured soft tissues via decreasing inflammatory mediators prostaglandin E2 and reducing injury animal blood viscosity.

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