Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (24): 4522-4524.doi: 10.3969/j.issn.1673-8225.2011.24.038

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Decoy receptor 1 expression in the intervertebral discs

Yang Ji-kun, Zhang Guo-qing, Chen Bo-hua   

  1. Department of Spine Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao  266003, Shandong Province, China
  • Received:2011-03-01 Revised:2011-04-10 Online:2011-06-11 Published:2011-06-11
  • Contact: Zhang Guo-qing, Master, Professor, Chief physician, Department of Spine Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China
  • About author:Yang Ji-kun★, Studying for master’s degree, Department of Spine Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, Shandong Province, China yangjikun@126.com

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Abstract:

BACKGROUND: Decoy receptor 1 (DcR1), which acts as decoy receptors, is resistant to apoptosis induction by related apoptosis inducing ligand (TRAIL).
OBJECTIVE: To investigate the expression of the DcR1 (TRAIL-R3) protein in human herniated and normal lumbar intervertebral discs (IVD).
METHODS: The expression and distribution of DcR1 proteins were assessed by using immunohistochemistry in 20 herniated lumbar IVD and 8 normal lumbar IVD tissues samples following discoidectomy from January to September 2010.
RESULTS AND CONCLUSION: Percentage of nucleus pulposus and anulus fibrous cells with DCR1 expression was obviously more in the herniated group than in normal IVD group. The current results indicate that the expression of DCR1 rises after herniation.

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