Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (24): 4524-4527.doi: 10.3969/j.issn.1673-8225.2010.24.036

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Associations of transforming growth factor beta 1-509C/T site gene polymorphism with blood stasis syndrome of lumbar intervertebral disc protrusion and intervertebral disc degeneration

Xu Jian-wen1, Zhong Yuan-ming1, Ji Jing1, Li Zhi-fei1, Chen Wen-fu2, Su Jie-han3, Huang Zeng-chao2, Li Gui-huan1   

  1. 1 Department of Spinal Surgery, 2 Department of Radiology, the First Affiliated Hospital of Guangxi Traditional Chinese Medical University, Nanning  530023, Guangxi Zhuang Autonomous Region, China; 3 Central Laboratory, Public Health School of Guangxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Online:2010-06-11 Published:2010-06-11
  • About author:Xu Jian-wen☆, Doctor, Professor, Master’s supervisor, Department of Spinal Surgery, the First Affiliated Hospital of Guangxi Traditional Chinese Medical University, Nanning 530023, Guangxi Zhuang Autonomous Region, China tdhao@tom.com; jianwenme@sohu.com
  • Supported by:

    the Science Foundation of Guangxi Zhuang Autonomous Region, No. 0991163*; Key Program of Guangxi Traditional Chinese Medical University, No. ZD2006062*

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Abstract:

BACKGROUND: Blood stasis syndrome is common in lumbar intervertebral disk protrusion (LIDP) in traditional Chinese medical clinical practice, which lacks of ideal preventing and treating methods. Previous studies have reported that transforming growth factor β1 (TGF-β1) -509C/T site gene polymorphism may correlate to intervertebral disc degeneration (IDD). 
OBJECTIVE: To investigate the relationship among the blood stasis syndrome in LIDP, IDD and TGF-β1-509C/T site gene polymorphisms.
METHODS: Totally 120 LIDP patients who received treatments in Department of Orthopedics of First Affiliated Hospital of Guangxi Traditional Chinese Medical College from January 2008 to December 2009 were selected, including 60 blood stasis syndrome and 60 non-blood stasis syndrome. The TGF-β1-509C/T site gene polymorphisms were detected and the IDD indexes were observed. The relationships between TGF-β1-509C/T site gene polymorphisms and the blood stasis syndrome of LIDP were analyzed by logistic regression Forward methods. The grade of intervertebral disc degeneration consisted of mild, middle and severe according to nuclear magnetic resonance.
RESULTS AND CONCLUSION: The degenerative degree of lumbar intervertebral disk with TGF-β1 gene-509 CT was higher than CC and TT in LIDP patients, the blood stasis syndrome group was severer than the non-blood stasis syndrome group (P < 0.05). It was showed that the risk of syndrome of blood stasis of LIDP in patients with severe IDD was 1.818 folds of that in patients with mild and middle IDD (OR =1.818, 95%CI: 1.275-2.931, P < 0.05), and the risk further increased 2.038 folds after accumulating with TGF-β1-509C/T site gene polymorphisms (OR = 2.038, 95%CI:1.379-3.423, P < 0.05). Severe IDD may be one of the risk factors of syndrome of blood stasis of LIDP in Han ethnic population from Guangxi. Patients with TGF-β1 gene-509 adiponectin CT genotype and combined with severe IDD are susceptible to syndrome of blood stasis of LIDP.

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