Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (15): 2801-2804.doi: 10.3969/j.issn.1673-8225.2010.15.034

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Significance of endothelial progenitor cells for tissue engineered skin construction  

Liu Hai-ping1, Wang Hong1, Dong Xiao-hua2, Yang Hua1   

  1. 1 Department of Burns, Second Affiliated Hospital, Kunming Medical College, Burn Research Center of Yunnan Province, Kunming   650000, Yunnan Province, China; 2 Department of Cardiology, First Affiliated Hospital, Kunming Medical College, Kunming   650000, Yunnan Province, China
  • Online:2010-04-09 Published:2010-04-09
  • Contact: Wang Hong, Professor, Chief physician, Master’s supervisor, Department of Burns, Second Affiliated Hospital, Kunming Medical College, Burn Research Center of Yunnan Province, Kunming 650000, Yunnan Province, China whkunming631015@sina.com
  • About author:Liu Hai-ping★, Studying for master’s degree, Department of Burns, Second Affiliated Hospital, Kunming Medical College, Burn Research Center of Yunnan Province, Kunming 650000, Yunnan Province, China l.xp1982@163.com
  • Supported by:

    the National Natural Science Foundation of China, No. 30760260*; the Foundation of Yunnan Scientific Plan, No. 2007C247M*

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Abstract:

BACKGROUND: Vascular endothelial progenitor cells can accumulate the vascularization in ischemic region.
OBJECTIVE: To analyze how to accelerate tissue engineered skin vascularization by endothelial progenitor cells.
METHODS: A computer-based online search was conducted in China Academic Journals Database and PubMed with the key words of “endothelial progenitor cell (EPC), tissue engineered skin, vascularization” in both English and Chinese from September 1999 to September 2009. Inclusion criteria: Articles were highly correlated with endothelial progenitor cells and tissue engineered skin development, including biological characteristics, stimulating methods, and mechanism of promoting vascular production of endothelial progenitor cells; current situation of tissue engineered skin; current situation of endothelial progenitor cells for tissue engineered skin construction.
RESULTS AND CONCLUSION: The endothelial progenitor cells belonged to a crowd of cells which specifically homed on vascular cambium, as well as differentiated and proliferated into mature endothelial cells. Nowadays, a lot of animal tests proved that it could accelerate the vascularization in ischemic region by transplanting the in vitro cultured endothelial progenitor cells into the ischemic region. The clinical application would be true when auto-endothelial progenitor cells have been successfully used to treat myocardial infarction. However, the tissue engineered skin was in defect of vessel, which seriously influenced the cell survival of human skin and the functional achievement. Therefore, how to construct artificial skin which was rich in vessels and how to accelerate the human skin substitution vascularization have attracted more attention. It is of significance for endothelial progenitor cells to promote tissue engineered skin vascularization so as to increase the survival rate.

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