Abstract:

BACKGROUND: Bone tissue engineering becomes a research focus since its conception, method, condition and perspective was proposed systematically by Crane GM in 1995.    
OBJECTIVE: To seek the value of bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2) in bone tissue engineering research through retrieving the advanced of bone tissue engineering from 1995.
METHODS: Articles published in CNKI and Pubmed databases were searched by computer with key words of “bone tissue engineering, BMP, FGF, and cytokine”. According to inclusive and exclusive criteria, 36 documents were remained for the further analysis. 
RESULTS AND CONCLUSION: Three main objects are applied to bone tissue engineering, including seed cell, cytokine and scaffold. Cytokine is very important in bone tissue engineering, which including bone morphogenetic protein, transforming growth factor, vascular endothelial growth factor, fibroblast growth factor, insulin-like growth factor and platelet-derived growth factor, et al. The bone morphogenetic protein-2 and fibroblast growth factor-2 are widely used in the bone tissue engineering.