Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (22): 4111-4114.doi: 10.3969/j.issn.1673-8225.2011.22.029

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Expression of nuclear factor kappa B and matrix metalloproteinases 3 in intervertebral disc degeneration

Yuan Ye1, Zhao Jing2, Li Yong-min1, Wang Xu1, Gu Shou-shan1   

  1. 1Department of Spinal Surgery, the Second Hospital of Tangshan, Tangshan  063000, Hebei Province, China
    2Department of Pathology, Hebei United University, Tangshan  063000, Hebei Province, China
  • Received:2011-01-09 Revised:2011-03-24 Online:2011-05-28 Published:2011-05-28
  • Contact: Zhao Jing, Associate professor, Department of Pathology, Hebei United University, Tangshan 063000, Hebei Province, China zhaojingts@163.com
  • About author:Yuan Ye★, Master, Associate chief physician, Department of Spinal Surgery, the Second Hospital of Tangshan, Tangshan 063000, Hebei Province, China yuanyets@163.com
  • Supported by:

    the Natural Science Instruction Plan of Hebei Education Bureau, No. Z2005102*

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Abstract:

BACKGROUND: During intervertebral disc degeneration, various cytokines, adhesion molecules, chemokines, inflammatory neurotransmitters, protein enzymes play an important role.
OBJECTIVE: To study the expression and significance of nuclear factor kappa B (NF-κB) and matrix metalloproteinases 3 (MMP-3) in normal disc tissue and intervertebral disc degeneration.
METHODS: Sixty-eight patients with intervertebral disc degeneration from surgical intervention for cervical disc herniation (lesion group) and 10 cases of normal disc tissue (control group) were included. The expressions of NF-κB and MMP-3 were tested by hematoxylin-eosin staining, immunohistochemistry method and ELISA.
RESULTS AND CONCLUSION: The NF-κB and MMP-3 positive expression rate was higher in the control group (P < 0.05). There was a positive correlation (r=0.643 0, P< 0.01). It indicated that NF-κB and MMP-3 may have important effects on intervertebral disc degeneration.

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