Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (22): 4028-4031.doi: 10.3969/j.issn.1673-8225.2011.22.010

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Curative effect of rivaroxaban versus low molecular weight heparin to prevent deep venous thrombosis following total hip arthroplasty

Jing Guang-wu1,2, Ye Shu-nan2,Yang Shu-hua2   

  1. 1Department of Orthopedics, Affiliated Hospital of Jianghan University, Wuhan  430015, Hubei Province, China
    2Department of Orthopedics, Union Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan  430022, Hubei Province, China
  • Received:2010-12-19 Revised:2011-03-17 Online:2011-05-28 Published:2011-05-28
  • About author:Jing Guang-wu★, Studying for master’s degree, Attending physician, Department of Orthopedics, Affiliated Hospital of Jianghan University, Wuhan 430015, Hubei Province, China; Department of Orthopedics, Union Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, Hubei Province, China jingguangwu@yahoo.cn

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Abstract:

BACKGROUND: Low molecular weight heparin can obviously reduce the incidence of deep venous thrombosis (DVT) following total hip arthroplasty (THA). However, subcutaneous injection limits the application of low molecular weight heparin.
OBJECTIVE: To observe the clinical effects and security of low molecular weight heparin and rivaroxaban against DVT after THA.
METHODS: Totally 58 THA patients were randomized into two groups: rivaroxaban group with 28 cases and heparin group with 30 cases. Occurrence of DVT and bleeding were observed under color Doppler of lower limbs.
RESULTS AND CONCLUSION: There was no statistics differences in DVT prevention and intraoperative bleeding between the two groups (P < 0.05). Rivaroxaban has similar effects to low molecular weight heparin on DVT prevention after THA.

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