Abstract:

BACKGROUND: After the formation of biofilm, drug resistance of bacteria was strong, and it could evade the host immune function and be difficultly eradicated at the site of infection. Therefore, it was one of important reasons of refractory infection in clinic.
OBJECTIVE: To review the research and progress of drug-resistant mechanisms of bacterial biofilm in order to find effective means and guide clinical use of drugs and drug discovery.
METHODS: Articles about drug-resistant mechanism of bacterial biofilm were retrieved from CNKI and PubMed with the key words of “iofilm; drug resistance; bacteria; infection” in both Chinese and English from January 1998 and December 2008. Articles in the same circle published in the authoritative journals or recently published were included. Among 285 articles, 23 were included in the final analysis.
RESULTS AND CONCLUSION: Understanding of the mechanisms of the bacterial biofilm formation helped us choose a more rational use of antibiotics and effective control over a good clinical infection. After the bacterium biofilm forming, the bacteria biofilm drug resistance increased obviously, but the mechanisms were not yet entirely clear, the action of biofilm ESS physical barrier, special micro-environment, bacterial quorum sensing systems and so on, all played roles in the resistance, they might be multi-factorial synergistic effect. The study of mechanism provides evidences for clinical medicine and drug discovery.