Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (12): 2191-2194.doi: 10.3969/j.issn.1673-8225.2010.12.025

Previous Articles     Next Articles

Mechanical property test for poly-L-lactic acid cervical absorbable fixing plate

Zheng Wei-dong1, Li Liang1, Zhang Pei-biao2, Li Guang-chun1, Zhao Shuan-zhu1   

  1. 1 Department of Spinal Surgery, People’s Hospital of Jilin Province, Changchun  130021, Jilin Province, China; 2 Changchun Institute of Applied Chemistry, Changchun  130021, Jilin Province, China
  • Online:2010-03-19 Published:2010-03-19
  • Contact: Li Liang, Doctor, Attending physician, Department of Spinal Surgery, People’s Hospital of Jilin Province, Changchun 130021, Jilin Province, China
  • About author:Zheng Wei-dong, Chief physician, Professor, Master’s supervisor, Department of Spinal Surgery, People’s Hospital of Jilin Province, Changchun 130021, Jilin Province, China Zhengwd2018@sina.com
  • Supported by:

    the Scientific and Technological Planning Project of Jilin Province, No. 20060414-3*

PDF

842

Abstract:

BACKGROUND: Previous study has prepared a novel absorbable fixation plates utilizing the limited fixation strength and absorbable characteristics of poly-L-lactic acid (PLLA).
OBJECTIVE: To test the mechanical property of PLLA absorbable fixation plates by in vivo degradation and mechanics experiments. 
METHODS: Fixation plates with 30 mm length, 5.5 mm width, and 2.0 mm thickness were selected. After ethylene oxide sterilization, the plates were implanted to the back muscles of 15 rabbits. At 1, 3, 5 and 7 months after operation, the plates were removed and the biodegradability and mechanical variation were observed.
RESULTS AND CONCLUSION: No significant change appeared in appearance after the materials were implanted in vivo at 1-5 months. There was no obvious change in volume and quality after 1-7 months. Mechanical test results showed that impact strength changed insignificantly after 1 month, followed a slight decrease after 3 months, then increased gradually, which met or exceeded the level before surgery at the end of 7 months. Bending strength decreased gradually over time with insignificant amplitude at 7 months after surgery. Torsional strength decreased insignificantly at 3-7 months after surgery. The results demonstrated that bio-mechanical strength of PLLA is sufficient to maintain the whole process of bony fusion. Anterior cervical fixation plate made of PLLA can be used for anterior cervical fusion and fixation.

CLC Number: