Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (21): 3949-3952.doi: 10.3969/j.issn.1673-8225.2011.21.035

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In vitro degradation and clinical application of lactide-glycolic acid copolymer as ureteral stent materials

Yu Yin-hua   

  1. Second Hospital of Zhangjiakou City, Zhangjiakou  075000, Hebei Province, China
  • Received:2011-01-09 Revised:2010-03-11 Online:2011-05-21 Published:2011-05-21
  • About author:Yu Yin-hua, Attending physician, Second Hospital of Zhangjiakou City, Zhangjiakou 075000, Hebei Province, China zjkdongjiang@sina.com

Abstract:

BACKGROUND: Complications exist after transplantation of different forms of ureteral stents. Therefore, how to choose the appropriate stent to treat urinary tract disease is the medical research focus.
OBJECTIVE: To investigate the in vitro degradation rule and clinical application of lactide-glycolic acid copolymer used as ureteral stent materials.
METHODS: The first author searched PubMed (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang databases (http://www.wanfangdata.com.cn) for relevant articles published from 1991-01 to 2009-12 with the keywords of “SR-PLGA; in-vitro degradation; degradalion rate” in English and Chinese. Old and repetitive articles were excluded, and finally 17 of 135 articles were included.
RESULTS AND CONCLUSION: There are few reports about the in vivo biodegradable properties of biodegradable polymer ureteral stent materials. As a biodegradable polymer material, natural degradation and compatibility is the primary condition for clinical application. It is of significance to understand material degradation and compatibility in clinical application. Lactide-glycolic acid copolymer as biodegradable ureteral stent material has a good biocompatibility, and the degradation rate of this copolymer can be effectively regulated by adjusting the glycolide and lactide component ratio.

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