Abstract:

BACKGROUND: Domestic and foreign scholars have used biological, non-biological, drug and other methods, such as biofilm, sodium hyaluronate, cellulose sealant, to perform a large number of studies on anti-adhesion tendon repair. However, there is no breakthrough up to now.
OBJECTIVE: To observe the proliferation of connective tissues after implantation of streptomycin combined with slow-releasing biodegradable membrane.
METHODS: After tendon cutting, SD rats were randomly divided into three groups: In group A, streptomycin combined with slow-releasing biodegradable membrane was implanted into the sutured site of Achilles tendon; in group B, vitamin C combined with slow-releasing degradable membrane were implanted; in group C, single slow-releasing degradable membrane was used. After 90 days, histological observation was performed for tendon injury as well as tractus hydroxyproline content and biomechanics indexes were measured.
RESULTS AND CONCLUSION: In the group A, there were more fibroblasts and collagen fibers in the sutured site of Achilles tendon than its surrounding tissues, group B and group C. Surrounding the sutured site, many loose connective tissue with normal structure could be seen, but few hyperplastic connective tissues grew into the tendon. A clear demarcation existed between the tendon and its peripheral tissues. The content of hydroxyproline and the ultimate tensile strength in group A were higher than those of groups B and C. The findings show that streptomycin combined with slow-releasing biodegradable membrane can alleviate or prevent tendon adhesion through inhibiting peripheral connective tissue proliferation and preventing connective tissue to grow into the tendon.