Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (21): 3887-3890.doi: 10.3969/j.issn.1673-8225.2011.21.020

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Preparation and properties of chitosan/poly(ε-caprolactone) blend films

Min Xiang1,2, Tang Min-jian1,2, Jiao Yan-peng1,2 , Zhou Chang-ren1,2   

  1. 1Department of Materials Science and Engineering, Jinan University, Guangzhou  510632, Guangdong Province, China; 2Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Jinan University, Guangzhou  510632, Guangdong Province, China
  • Received:2011-01-26 Revised:2011-04-25 Online:2011-05-21 Published:2011-05-21
  • Contact: Zhou Chang-ren, Professor, Doctoral supervisor, Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, Guangdong Province, China; Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Jinan University, Guangzhou 510632, Guangdong Province, China tcrz9@jnu.edu.cn
  • About author:Min Xiang★, Studying for master’s degree, Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, Guangdong Province, China; Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Jinan University, Guangzhou 510632, Guangdong Province, China minxiang@yeah.net
  • Supported by:

    the National Natural Science Foundation of China, No. 50903039*; Doctoral Program of Higher Education Research Funding, No. 20094401120006*; the Natural Science Foundation of Guangdong Province, No. 9451063201002459*; Basic Research Funding for Key Colleges, No. 21609205*

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Abstract:

BACKGROUND: Chitosan/poly(ε-caprolactone) (Chitosan/PCL) blend has a perspective in biomaterials. However, it is still unknown that the correlation between protein adsorption and cell activity on blends.
OBJECTIVE: To investigation the correlation between protein adsorption behaviors and cell activities on chitosan/PCL blend films
METHODS: Chitosan/PCL films with different mass ratios were prepared by spin coating with chitosan/PCL mixture solution. Atomic force microscopy (AFM), drop shape analyzer (DSA), quartz crystal microbalance (QCM) and MTT method were used to analyze the surface morphology, hydrophilicity, protein adsorption and cell metabolic activity of films.
RESULTS AND CONCLUSION: The topography, hydrophilicity, protein adsorption and cell metabolic activity of films are largely related to the mass ratio of chitosan and PCL. The cell metabolic activity observed on hydrophobic PCL films is superior and cell adhesion level on hydrophilic chitosan films is excellent.

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