Abstract:

BACKGROUND: Currently, non-heparin-coated pipe and tube have a great impact on internal cardiopulmonary bypass (CPB) cardiac surgery, which can cause blood damage, heavy inflammatory response, and influence the postoperative recovery and survival of patients.
OBJECTIVE: To develop a new heparin-coated CPB pipe by using the bomedical polymer materials, and to study its stability and performance of anticoagulant.   
METHODS: CaCl2 was used to form Ca2+ membrane for modifying the inner surface of medical polyvinyl chloride (PVC) pipe cross-linking with sodium alginate and heparin. The Ca2+ reacted with Na+ which was in the sodium alginate and heparin, so that the linear polymer cross-linking molecules were to form chemical cross-linked sodium alginate-heparin complex network structure, a type of biomaterial heparin coating.
RESULTS AND CONCLUSION: CaCl2 modified activated medical PVC cardiopulmonary bypass pipe reacting with heparin and sodium alginate to bring out the cross-linking reaction and form biological polymers heparin-coating pipe. The heparin-coated pipe has been proved that it has good blood compatibility, stability, anti-coagulation performance to meet short-term extracorporeal circulation bypass.