Abstract:

BACKGROUND: Bone marrow mesenchymal stem cell transplantation is an effective method to treat exercise-induced spinal cord injury (SCI). However, the study concerning SCI is not enough, and lacks of exploration of its mechanism and good therapeutic methods.
OBJECTIVE: To provide theoretical basis and scientific support for rehabilitation treatment programs of exercise-induced SCI by analysis of pathological features of exercise-induced SCI, physiological characteristics of bone marrow mesenchymal stem cells and its application to SCI.
METHODS: We searched Pubmed database (1991/2010) with the key words of “mesenchymal stem cell, sports knee injuries”. VIP database was searched (1991/2010) with the key words of “bone marrow mesenchymal stem cell, sports knee injuries”.
RESULTS AND CONCLUSION: A total of 85 literatures were retrieved, and those published early or with poor quality were excluded. Finally, 25 literatures were included. Bone marrow mesenchymal stem cells were divided into neuron-like cells, reactive secretion of various nutrition factors and growth factors to promote neuroprotective effect and promote local microvessel regeneration, resulting in treating SCI. However, related problems that affected the differentiation and its results of bone marrow mesenchymal stem cells such as ischemia, hypoxia and production of sports free radical and excitatory amino acids following exercise-induced SCI in the injury region require further investigations.