Abstract:

BACKGROUND: Previous studies have confirmed that the outcome of hematopoietic stem cell transplantation for treatment of type 1 diabetes mellitus is identified.
OBJECTIVE: To observe the safety and efficacy of autologous hematopoietic stem cells transplantation in treatment of type 1 diabetes mellitus combined with hypothyroidism.
METHODS: A total of two cases of type 1 diabetes mellitus and hypothyroidism were subjected to immune clearance and hematopoietic stem cell transplantation. The hematopoietic stem cell mobilization, collection, immune suppression and hematopoietic stem cell reinfusion all achieved satisfactory results. Insulin, levothyroxine sodium content, serum C peptide mass concentration, glycosylated hemoglobin level and thyroid gland function differences were compared prior to and following treatment.
RESULTS AND CONCLUSION: C peptide mass concentration recovered to normal in 1 case following treatment. Insulin was withdrawn. Dose of thyroxine tablets was reduced and thyroid function resulted in the normal range. In another case, insulin dose reduced by 64%. Withdraw of thyroxine tablets resulted in normal thyroid function. These indicated that it is safe to treat type 1 diabetes mellitus combined with hypothyroidism, resulting in obvious short-term outcomes.