Application of striping and local injections in patients with auricle keloid

doi:10.3969/j.issn.2095-4344.2014.46.010

Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (46): 7427-7431.doi: 10.3969/j.issn.2095-4344.2014.46.010

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Application of striping and local injections in patients with auricle keloid

Tang Jie, Li Xiao-jing, Tang Yue-ling, Ning Jin-long

Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China

Revised:2014-10-31 Online:2014-11-12 Published:2014-11-12
Contact: Li Xiao-jing, Master, Chief physician, Professor, Master’s supervisor, Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
About author:Tang Jie, Studying for master’s degree, Physician, Department of Orthopaedics, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Supported by:
the Natural Science Foundation of Anhui Province, No. 11040606M202; the National Natural Science Foundation of China, No. 81272107

Abstract

Abstract:

BACKGROUND: Keloids are the result of abnormal post-traumatic skin restoration, which are characterized with overgrowth and progressive enlargement, invasion of adjacent normal skin tissue, extension beyond the scope of the original wound. Given the high recurrence, treatment with surgery alone is meaningless and, therefore, comprehensive treatment of surgery and other approaches is required.

OBJECTIVE: To explore the clinical curative effect of local injection after timely removal of auricle keloid core.

METHODS: Twenty patients with auricle keloid were enrolled. After keloid core excision, the time interval within the incision scar tissue injection of fluorouracil or triamcinolone acetonide add lidocaine or monotherapy was gradually lengthened, and if necessary the proper amount of compound betamethasone was added according to scar conditions. The injection dose was adjusted timely based on the regression of scar. The treatment effect was observed for 12 to 24 months.

RESULTS AND CONCLUSION: Of 36 auricle keloids from 20 patients, the comprehensive treatment was effective in 1 keloid, and other 35 keloids were cured. The effective rate was 100%, the completely cured rate was 97.2% and the excellent rate was 2.8%. These findings indicate that minimally invasive excision of keloid core and the epithelial flap coverage combined with 5-fluorouracil and corticosteroid injection is a safe and effective method to treat auricle keloids.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: keloid, triamcinolone acetonide, fluorouracil

CLC Number:

R318

Tang Jie, Li Xiao-jing, Tang Yue-ling, Ning Jin-long. Application of striping and local injections in patients with auricle keloid [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(46): 7427-7431.

Figures/Tables 1

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Application of striping and local injections in patients with auricle keloid

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