Abstract:

BACKGROUND: To reduce the infection of hernia repair mesh, the research group combined silver with medical polypropylene (PP) mesh, to obtain good antibacterial properties, thus not only reducing infection rates of hernia repair mesh, and further applying to potential contaminated and contaminated wounds, widening the application range of tension-free hernia repair.
OBJECTIVE: To evaluate the security of medical PP mesh implanted in animals.
METHODS: According to the biological and animal experiments recommended by international standards (ISO 10993 series) and national standard (GB/T 16886 series): After the argentation PP mesh was implanted in rabbits, we observed rabbit body weight, death, inflammation, blood biochemistry, liver and kidney function indicators at different periods. Hepatic tissue pathological sections were evaluated for acute, subacute and chronic toxic reactions.
RESULTS AND CONCLUSION: After the argentation PP mesh was implanted, the rabbits had no obvious toxic reactions or death. There was no significant difference between the experimental group and control group in blood inflammatory, blood biochemistry, liver and kidney function indicators and liver tissue hematoxylin-eosin staining (P > 0.05), the mesh meets the transformation rule of general inflammation indicators. Argentation medical PP mesh has a good safety in vivo.